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Extensive Stage Lung Small Cell Carcinoma

MedGen UID:
124501
•Concept ID:
C0278726
•
Neoplastic Process
Synonyms: Extensive Disease Small Cell Lung Cancer; Extensive Disease Small Cell Lung Carcinoma; Extensive Stage SCLC; Extensive Stage Small Cell Carcinoma of Lung; Extensive Stage Small Cell Carcinoma of the Lung; Extensive Stage Small Cell Lung Carcinoma; Small Cell Lung Cancer, Extensive Stage

Definition

Small cell lung carcinoma which has spread beyond one hemi-thorax and the regional lymph nodes. [from NCI]

Professional guidelines

PubMed

FRESC: French Real world Extensive stage SCLC Cohorts: A retrospective study on patient characteristics and treatment strategy based on KBP-2010.
Debieuvre D, Dayen C, Dixmier A, Pau D, Sibley-Revelat A, Greenwood W, Gally S, Falchero L
Lung Cancer 2022 Feb;164:1-7. Epub 2021 Dec 18 doi: 10.1016/j.lungcan.2021.11.013. PMID: 34954472
Immunotherapy versus standard chemotherapy for treatment of extensive-stage small-cell lung cancer: a systematic review.
Liu X, Xing H, Zhang H, Liu H, Chen J
Immunotherapy 2021 Aug;13(12):989-1000. Epub 2021 Jun 11 doi: 10.2217/imt-2020-0284. PMID: 34114477
Treatment of extensive-stage small cell lung carcinoma: current status and future prospects.
Demedts IK, Vermaelen KY, van Meerbeeck JP
Eur Respir J 2010 Jan;35(1):202-15. doi: 10.1183/09031936.00105009. PMID: 20044461

Recent clinical studies

Etiology

Effect of First-Line Serplulimab vs Placebo Added to Chemotherapy on Survival in Patients With Extensive-Stage Small Cell Lung Cancer: The ASTRUM-005 Randomized Clinical Trial.
Cheng Y, Han L, Wu L, Chen J, Sun H, Wen G, Ji Y, Dvorkin M, Shi J, Pan Z, Shi J, Wang X, Bai Y, Melkadze T, Pan Y, Min X, Viguro M, Li X, Zhao Y, Yang J, Makharadze T, Arkania E, Kang W, Wang Q, Zhu J; ASTRUM-005 Study Group
JAMA 2022 Sep 27;328(12):1223-1232. doi: 10.1001/jama.2022.16464. PMID: 36166026Free PMC Article
Durvalumab, with or without tremelimumab, plus platinum-etoposide versus platinum-etoposide alone in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): updated results from a randomised, controlled, open-label, phase 3 trial.
Goldman JW, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, Statsenko G, Hochmair MJ, Özgüroğlu M, Ji JH, Garassino MC, Voitko O, Poltoratskiy A, Ponce S, Verderame F, Havel L, Bondarenko I, Każarnowicz A, Losonczy G, Conev NV, Armstrong J, Byrne N, Thiyagarajah P, Jiang H, Paz-Ares L; CASPIAN investigators
Lancet Oncol 2021 Jan;22(1):51-65. Epub 2020 Dec 4 doi: 10.1016/S1470-2045(20)30539-8. PMID: 33285097
Design and Rationale for a Phase III, Randomized, Placebo-controlled Trial of Durvalumab With or Without Tremelimumab After Concurrent Chemoradiotherapy for Patients With Limited-stage Small-cell Lung Cancer: The ADRIATIC Study.
Senan S, Okamoto I, Lee GW, Chen Y, Niho S, Mak G, Yao W, Shire N, Jiang H, Cho BC
Clin Lung Cancer 2020 Mar;21(2):e84-e88. Epub 2019 Dec 28 doi: 10.1016/j.cllc.2019.12.006. PMID: 31948903
Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial.
Paz-Ares L, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, Statsenko G, Hochmair MJ, Özgüroğlu M, Ji JH, Voitko O, Poltoratskiy A, Ponce S, Verderame F, Havel L, Bondarenko I, Kazarnowicz A, Losonczy G, Conev NV, Armstrong J, Byrne N, Shire N, Jiang H, Goldman JW; CASPIAN investigators
Lancet 2019 Nov 23;394(10212):1929-1939. Epub 2019 Oct 4 doi: 10.1016/S0140-6736(19)32222-6. PMID: 31590988
First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer.
Horn L, Mansfield AS, Szczęsna A, Havel L, Krzakowski M, Hochmair MJ, Huemer F, Losonczy G, Johnson ML, Nishio M, Reck M, Mok T, Lam S, Shames DS, Liu J, Ding B, Lopez-Chavez A, Kabbinavar F, Lin W, Sandler A, Liu SV; IMpower133 Study Group
N Engl J Med 2018 Dec 6;379(23):2220-2229. Epub 2018 Sep 25 doi: 10.1056/NEJMoa1809064. PMID: 30280641

Diagnosis

Radiotherapy for extensive-stage small-cell lung cancer in the immunotherapy era.
Li H, Zhao Y, Ma T, Shao H, Wang T, Jin S, Liu Z
Front Immunol 2023;14:1132482. Epub 2023 Aug 28 doi: 10.3389/fimmu.2023.1132482. PMID: 37701437Free PMC Article
Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions.
Megyesfalvi Z, Gay CM, Popper H, Pirker R, Ostoros G, Heeke S, Lang C, Hoetzenecker K, Schwendenwein A, Boettiger K, Bunn PA Jr, Renyi-Vamos F, Schelch K, Prosch H, Byers LA, Hirsch FR, Dome B
CA Cancer J Clin 2023 Nov-Dec;73(6):620-652. Epub 2023 Jun 17 doi: 10.3322/caac.21785. PMID: 37329269
Small Cell Lung Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Ganti AKP, Loo BW, Bassetti M, Blakely C, Chiang A, D'Amico TA, D'Avella C, Dowlati A, Downey RJ, Edelman M, Florsheim C, Gold KA, Goldman JW, Grecula JC, Hann C, Iams W, Iyengar P, Kelly K, Khalil M, Koczywas M, Merritt RE, Mohindra N, Molina J, Moran C, Pokharel S, Puri S, Qin A, Rusthoven C, Sands J, Santana-Davila R, Shafique M, Waqar SN, Gregory KM, Hughes M
J Natl Compr Canc Netw 2021 Dec;19(12):1441-1464. doi: 10.6004/jnccn.2021.0058. PMID: 34902832Free PMC Article
Small-cell lung cancer.
Rudin CM, Brambilla E, Faivre-Finn C, Sage J
Nat Rev Dis Primers 2021 Jan 14;7(1):3. doi: 10.1038/s41572-020-00235-0. PMID: 33446664Free PMC Article
DLL3: an emerging target in small cell lung cancer.
Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K
J Hematol Oncol 2019 Jun 18;12(1):61. doi: 10.1186/s13045-019-0745-2. PMID: 31215500Free PMC Article

Therapy

Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions.
Megyesfalvi Z, Gay CM, Popper H, Pirker R, Ostoros G, Heeke S, Lang C, Hoetzenecker K, Schwendenwein A, Boettiger K, Bunn PA Jr, Renyi-Vamos F, Schelch K, Prosch H, Byers LA, Hirsch FR, Dome B
CA Cancer J Clin 2023 Nov-Dec;73(6):620-652. Epub 2023 Jun 17 doi: 10.3322/caac.21785. PMID: 37329269
Extensive-Stage Small-Cell Lung Cancer: First-Line and Second-Line Treatment Options.
Zugazagoitia J, Paz-Ares L
J Clin Oncol 2022 Feb 20;40(6):671-680. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01881. PMID: 34985925
Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial.
Paz-Ares L, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, Statsenko G, Hochmair MJ, Özgüroğlu M, Ji JH, Voitko O, Poltoratskiy A, Ponce S, Verderame F, Havel L, Bondarenko I, Kazarnowicz A, Losonczy G, Conev NV, Armstrong J, Byrne N, Shire N, Jiang H, Goldman JW; CASPIAN investigators
Lancet 2019 Nov 23;394(10212):1929-1939. Epub 2019 Oct 4 doi: 10.1016/S0140-6736(19)32222-6. PMID: 31590988
DLL3: an emerging target in small cell lung cancer.
Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K
J Hematol Oncol 2019 Jun 18;12(1):61. doi: 10.1186/s13045-019-0745-2. PMID: 31215500Free PMC Article
First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer.
Horn L, Mansfield AS, Szczęsna A, Havel L, Krzakowski M, Hochmair MJ, Huemer F, Losonczy G, Johnson ML, Nishio M, Reck M, Mok T, Lam S, Shames DS, Liu J, Ding B, Lopez-Chavez A, Kabbinavar F, Lin W, Sandler A, Liu SV; IMpower133 Study Group
N Engl J Med 2018 Dec 6;379(23):2220-2229. Epub 2018 Sep 25 doi: 10.1056/NEJMoa1809064. PMID: 30280641

Prognosis

Radiotherapy for extensive-stage small-cell lung cancer in the immunotherapy era.
Li H, Zhao Y, Ma T, Shao H, Wang T, Jin S, Liu Z
Front Immunol 2023;14:1132482. Epub 2023 Aug 28 doi: 10.3389/fimmu.2023.1132482. PMID: 37701437Free PMC Article
Emerging Strategies for the Treatment of Small Cell Lung Cancer: A Review.
Petty WJ, Paz-Ares L
JAMA Oncol 2023 Mar 1;9(3):419-429. doi: 10.1001/jamaoncol.2022.5631. PMID: 36520421
Immunotherapy in Lung Cancer: Current Landscape and Future Directions.
Mamdani H, Matosevic S, Khalid AB, Durm G, Jalal SI
Front Immunol 2022;13:823618. Epub 2022 Feb 9 doi: 10.3389/fimmu.2022.823618. PMID: 35222404Free PMC Article
Small-cell lung cancer.
Rudin CM, Brambilla E, Faivre-Finn C, Sage J
Nat Rev Dis Primers 2021 Jan 14;7(1):3. doi: 10.1038/s41572-020-00235-0. PMID: 33446664Free PMC Article
Durvalumab plus platinum-etoposide versus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial.
Paz-Ares L, Dvorkin M, Chen Y, Reinmuth N, Hotta K, Trukhin D, Statsenko G, Hochmair MJ, Özgüroğlu M, Ji JH, Voitko O, Poltoratskiy A, Ponce S, Verderame F, Havel L, Bondarenko I, Kazarnowicz A, Losonczy G, Conev NV, Armstrong J, Byrne N, Shire N, Jiang H, Goldman JW; CASPIAN investigators
Lancet 2019 Nov 23;394(10212):1929-1939. Epub 2019 Oct 4 doi: 10.1016/S0140-6736(19)32222-6. PMID: 31590988

Clinical prediction guides

Emerging Strategies for the Treatment of Small Cell Lung Cancer: A Review.
Petty WJ, Paz-Ares L
JAMA Oncol 2023 Mar 1;9(3):419-429. doi: 10.1001/jamaoncol.2022.5631. PMID: 36520421
Immunotherapy in Lung Cancer: Current Landscape and Future Directions.
Mamdani H, Matosevic S, Khalid AB, Durm G, Jalal SI
Front Immunol 2022;13:823618. Epub 2022 Feb 9 doi: 10.3389/fimmu.2022.823618. PMID: 35222404Free PMC Article
Radiation and Systemic Therapy for Limited-Stage Small-Cell Lung Cancer.
Bogart JA, Waqar SN, Mix MD
J Clin Oncol 2022 Feb 20;40(6):661-670. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01639. PMID: 34985935Free PMC Article
Extensive-Stage Small-Cell Lung Cancer: First-Line and Second-Line Treatment Options.
Zugazagoitia J, Paz-Ares L
J Clin Oncol 2022 Feb 20;40(6):671-680. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01881. PMID: 34985925
First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer.
Horn L, Mansfield AS, Szczęsna A, Havel L, Krzakowski M, Hochmair MJ, Huemer F, Losonczy G, Johnson ML, Nishio M, Reck M, Mok T, Lam S, Shames DS, Liu J, Ding B, Lopez-Chavez A, Kabbinavar F, Lin W, Sandler A, Liu SV; IMpower133 Study Group
N Engl J Med 2018 Dec 6;379(23):2220-2229. Epub 2018 Sep 25 doi: 10.1056/NEJMoa1809064. PMID: 30280641

Recent systematic reviews

Efficacy and safety of first-line immunotherapy plus chemotherapy in treating patients with extensive-stage small cell lung cancer: a Bayesian network meta-analysis.
Zhang T, Li W, Diwu D, Chen L, Chen X, Wang H
Front Immunol 2023;14:1197044. Epub 2023 Jun 26 doi: 10.3389/fimmu.2023.1197044. PMID: 37435087Free PMC Article
Chemo-Immunotherapy in First Line Extensive Stage Small Cell Lung Cancer (ES-SCLC): A Systematic Review and Meta-Analysis.
Sathiyapalan A, Febbraro M, Pond GR, Ellis PM
Curr Oncol 2022 Nov 22;29(12):9046-9065. doi: 10.3390/curroncol29120709. PMID: 36547123Free PMC Article
Comparison of atezolizumab, durvalumab, pembrolizumab, and nivolumab as first-line treatment in patients with extensive-stage small cell lung cancer: A systematic review and network meta-analysis.
Chen J, Wang J, Xu H
Medicine (Baltimore) 2021 Apr 16;100(15):e25180. doi: 10.1097/MD.0000000000025180. PMID: 33847617Free PMC Article
Comparison of First-Line Treatments for Patients With Extensive-Stage Small Cell Lung Cancer: A Systematic Review and Network Meta-analysis.
Zhou T, Zhang Z, Luo F, Zhao Y, Hou X, Liu T, Wang K, Zhao H, Huang Y, Zhang L
JAMA Netw Open 2020 Oct 1;3(10):e2015748. doi: 10.1001/jamanetworkopen.2020.15748. PMID: 33074323Free PMC Article
Thoracic Radiotherapy for Extensive Stage Small-Cell Lung Cancer: A Meta-Analysis.
Palma DA, Warner A, Louie AV, Senan S, Slotman B, Rodrigues GB
Clin Lung Cancer 2016 Jul;17(4):239-44. Epub 2015 Oct 1 doi: 10.1016/j.cllc.2015.09.007. PMID: 26498503

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